Stadium Bosuil Stadion
Leko is unlikely to make major alterations to the side which edged out Beerschot at the weekend.
Former Manchester United and Leicester City defender Ritchie De Laet should feature in a three-man backline, while Aurelio Buta could come into the side at wing-back.
Royal Antwerp possible starting lineup:
Butez; Seck, Gelin, De Laet; Buta, Haroun, Hongla, Juklerod; Gerkens, Mbokani, Refaelov
Royal Antwerp Europa League form: W
Royal Antwerp form (all competitions): DWWWWW
Bale and Vinicius will almost certainly start in attack for Spurs, likely being joined by Erik Lamela.
Of the players who started the fixture with Burnley on Monday evening, Ben Davies and Moussa Sissoko may be the only players who keep their place in the side.
Although Dele Alli did not feature in the 18-man squad at Turf Moor, the England international is in line to feature among the substitutes.
Tottenham Hotspur possible starting lineup:
Hart; Aurier, Sanchez, Davies, Reguilon; Sissoko, Winks; Lamela, Lo Celso, Bale; Vinicius
Tottenham Hotspur Europa League form: WWWW
Tottenham Hotspur form (all competitions): WWWDWW
Prediction: Royal Antwerp 1-4 Tottenham Hotspur