African genomics venture 54gene launches clinical research in Nigeria


“Alongside key partners like Certara and other important stakeholders across the continent, the UNITY Global Study is a great opportunity for some of the best clinical teams across Sub-Saharan Africa to come together and ensure outcomes of any COVID-19 studies are relevant to Africans. The insights generated from this program could potentially unlock breakthrough clinical discoveries that can improve health outcomes for millions of people globally.”

The UNITY Global study aims to develop prevention policies based on real-world data collected from 10,000 healthcare workers in low and middle income countries, including Pakistan, Nigeria, South Africa, Kenya, Uganda, Senegal, Zambia and Zimbabwe. The registry’s primary objective is to examine the link between the use of preventive treatments and the occurrence of SARS-CoV-2 infection in healthcare workers providing care to patients with COVID-19. With the nature of the virus and its impact on the global healthcare system, it is crucial to develop guidance and policies for protecting healthcare workers, who are at the frontline of combating the disease.  

The registry will collect information on a weekly basis from enrollees across a 12-week period. Data collection includes medications being taken by healthcare workers, their level of exposure to COVID-19 patients, their health status, and other factors such as the use of personal protective equipment (PPE), which would likely mitigate their risk of SARS-CoV-2 infection.  In addition, the registry will record SARS-CoV-2 antibody test results. The study is funded by a grant from the COVID-19 Therapeutics Accelerator.* 

Roman Casciano, general manager of Certara’s evidence and access group added: “Healthcare workers have a high incidence of severe COVID-19 as they are repeatedly exposed to individuals infected with SARS-CoV-2. With limited evidence on the effectiveness of the preventative measures and treatments currently being used, collaborating with key partners such as 54gene is invaluable for expanding the current body of research.”

“Through our country partners’ support and findings from the registry, we hope to provide meaningful data to inform decision making that will help protect healthcare workers worldwide battling COVID-19 on the frontlines.”








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